Methods and compositions for regulating protein-protein interactions
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsKun Ping Lu, Xiao Zhen Zhou
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Abstract
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
Claims7
A method of inhibiting the prolyl-peptidyl cis-trans isomerase activity of a Pin1 polypeptide in a cell comprising, contacting a cell expressing Pin-1 with a substance, wherein the substance inhibits the binding of a Pin1 WW-domain with a phosphorylated ligand in the cell.
Dependencies are inferred from the claim text.