Orally dissolvable nutritional supplement
AssigneeWarner Chilcott Laboratories Ireland Limited
InventorsTina deVries, William Valentine, William K. Valentine
Life of this patent
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Abstract
The present invention provides an orally administrable nutritional supplement which is highly palatable, such as a chewable prenatal vitamin/mineral supplement. The supplement is preferably made in the form of a tablet that, upon chewing, dissolves rapidly in the mouth. The tablet is particularly suitable for administration of vitamins and minerals to women during pregnancy. The invention also includes methods of making and using such supplements.
Claims29
A chewable prenatal nutritional supplement which comprises a prenatally relevant amount of folic acid, a prenatally relevant amount of iron, and an alkyl polysiloxane, wherein the supplement is substantially free of calcium.
A chewable prenatal nutritional supplement in a unit dosage form which comprises a prenatally relevant amount of at least one vitamin or mineral and an alkyl polysiloxane, and wherein the unit dosage form comprises
- (a) about 0.1-2.0 milligrams of folic acid, or a pharmaceutically acceptable salt form thereof;
- (b) about 100-800 International Units (I.U.) of vitamin D3;
- (c) about 100-4000 I.U. of beta carotene or another pharmaceutically acceptable form of vitamin A;
- (d) about 0.2-8 milligrams of vitamin B1;
- (e) about 0.5-10 milligrams of vitamin B2;
- (f) about 2-200 milligrams of vitamin B6;
- (g) about 2-20 micrograms of vitamin B12;
- (h) about 1-200 I.U. of vitamin E;
- (i) about 20-200 milligrams of vitamin C in the form of ascorbic acid and/or a pharmaceutically acceptable salt thereof;
- (j) about 5-40 milligrams of niacinamide or an equivalent molar amount of niacin;
- (k) about 1-100 milligrams of elemental iron in the form of a pharmaceutically acceptable iron compound.
A method of making a chewable prenatal nutritional supplement, the method comprising mixing a prenatally relevant amount of folic acid and a prenatally relevant amount of iron with an alkyl polysiloxane to yield a mixture and incorporating the mixture into an orally administrable dosage form, and wherein the supplement is substantially free of calcium.
A method of making a chewable prenatal nutritional supplement, the method comprising mixing a prenatally relevant amount of at least one vitamin or mineral with an alkyl polysiloxane to yield a mixture and incorporating the mixture into an orally administrable dosage form, wherein the mixture is formed by mixing the alkyl polysiloxane with
- (a) folic acid;
- (b) vitamin D3;
- (c) vitamin A;
- (d) vitamin B1;
- (e) vitamin B2;
- (f) vitamin B6;
- (g) vitamin B12;
- (h) vitamin E;
- (i) vitamin C;
- (j) one of niacinamide and niacin;
- and
- (k) an iron compound.
A method of alleviating a nutritional disorder in a human, the method comprising administering to the human a chewable prenatal nutritional supplement which comprises
- a prenatally relevant amount of folic acid, a prenatally relevant amount of iron, and
- about 1-100 milligrams of an alkyl polysiloxane, wherein the amount of the alkyl polysiloxane is less than one weight percent of the supplement and wherein the supplement is substantially free of calcium.
In a method of alleviating a nutritional disorder in a human by administering a chewable prenatal nutritional supplement comprising a prenatally relevant amount of folic acid and a prenatally relevant amount of iron to the human, the improvement comprising incorporating about 1-100 milligrams of an alkyl polysiloxane in the supplement, wherein the amount of the alkyl polysiloxane is less than one weight percent of the supplement, and wherein the supplement is substantially free of calcium.
Dependencies are inferred from the claim text.