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US 6,495,156 B2Granted
Biocements having improved compressive strength
AssigneeMerck Patent GmbH
InventorsRobert Wenz, Ferdinand Driessens
Life of this patent
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Abstract
The invention describes biodegradable calcium phosphate cements, in particular mixtures of calcium phosphate-containing powders of different stoichiometric composition, the precipitated hydroxylapatite present being a cation-deficient hydroxylapatite of the formula 1, with the result that the mixtures have improved properties with regard to compressive strength.
Claims23
A mixture of powders suitable for preparation of absorbable calcium phosphate cements comprising:
- tricalcium phoshate (TCP) in which,
- 30 to 70% of the TCP particles have a particle size of 0.1 to 7 um and
- 10 to 60% of the TCP particles have a particle size of 40 to 100 um;
- precipitated hydroxylapatite (PHA) wherein the PHA is a cation-deficient hydroxylapatite of the formula I
- Ca8.75V(Ca)1.25[(HPO4)5.5-x(CO3)0.5](OH)xV(OH)2-x
- in which x is 0-2;
- and
- at least one other phosphate-containing inorganic compound.
5 more elements
A mixture of powders suitable for preparation of absorbable calcium phosphate cements comprising:
- tricalcium phoshate (TCP) in which,
- 30 to 70% of the TCP particles have a particle size of 0.1 to 7 um and
- 10 to 60% of the TCP particles have a particle size of 40 to 100 um;
- precipitated hydroxylapatite (PHA) wherein the PHA is a cation-deficient hydroxylapatite of the formula I Ca8.75V(Ca)1.25[(HPO4)5.5-x(CO3)0.5](OH)xV(OH)2-x in which x is 0-2;
- and
- CaCO3.
3 more elements
Dependencies are inferred from the claim text.