Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use
AssigneeCohesion Technologies, Inc.
InventorsDonald G. Wallace, George H. Chu, Jacqueline Anne Schroeder
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Abstract
The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures and medical staples.
Claims81
A composition for forming a matrix useful as a high strength medical sealant, wherein said matrix-forming composition comprises:
- a) a first multifunctional synthetic polymer having a core and m functional groups, X;
- b) a multifunctional crosslinker having n functional groups, Y, wherein the sum of m and n is greater than or equal to 5, and X and Y react to form a covalent crosslink Z upon admixture of the first multifunctional synthetic polymer and the multifunctional crosslinker;
- and
- c) a tensile strength enhancer comprised of a fibrous material selected from the group consisting of polyglycolide, polylactide, polyglycolide-polylactide copolymers, glass wool, plastics, resins, and combinations thereof,
- wherein the high strength medical sealant formed by reaction of the first multifunctional synthetic polymer with the multifunctional crosslinker has at least 10% of the tensile strength of cyanoacrylate.
A composition for forming a matrix useful as a high strength medical sealant, wherein said matrix-forming composition comprises:
- a) a polyalkylene oxide having n nucleophilic groups, X;
- b) a polyalkylene oxide having n electrophilic groups, Y, wherein the sum of m and n is greater than or equal to 5, and X and Y react to form a covalent crosslink Z upon admixture of a) and b) under crosslinking conditions;
- c) a rigid nanofiber;
- and
- d) a fibrous tensile strength enhancer, and
- wherein the high strength medical sealant formed by reaction of a) and b) has at least 10% of the tensile strength of cyanoacrylate.
A biocompatible polymer device for use in treating tissues comprising a collagen sponge or sheet incorporated with a two-part reactive polyethylene glycol powder, wherein said reactive powder further comprises a first polyethylene glycol having multiple nucleophilic groups and a second polyethylene glycol having multiple electrophilic groups, wherein the polyethylene glycol powder remains unreactive until contacted with a high pH buffer.
A system for forming a high strength medical sealant, comprising:
- a) a first multifunctional synthetic polymer having a core and m functional groups, X;
- b) a multifunctional crosslinker having n functional groups, Y, wherein X and Y react to form a covalent crosslink Z upon admixture of the first multifunctional synthetic polymer and the multifunctional crosslinker, and further wherein the first multifunctional synthetic polymer and the multifunctional crosslinker are physically separated from each other until reaction therebetween is desired;
- c) a tensile strength enhancer comprised of fibers 5 to 40 microns in diameter and 20 to 5000 microns in length and having a glass transition temperature above 37° C.;
- and
- d) a rigid nanofiber,
- wherein the high strength medical sealant formed upon reaction of the first multifunctional synthetic polymer and the multifunctional crosslinker has at least 10% of the tensile strength of cyanoacrylate.
Dependencies are inferred from the claim text.