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US 6,495,016 B1Granted
Microfluidic microchip with integrated substance injection
AssigneeAgilent Technologies, Inc.
InventorBernd Nawracala
Life of this patent
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AssigneeAgilent Technologies, Inc.
InventorBernd Nawracala
Estimating the term…
A microfluidic microchip includes a channel structure having a delivery channel connected in a substance conductive manner to a separation channel. Laterally offset discharge channels are at connection points displaced from a connection point between the delivery and separation channels. Between the connection points on the one hand and the connection point on the other are channel sections having concordant channel lengths. By imposing suitable electrical potentials along these channel sections, the filling volumes present in the channel sections are satisfactorily homogenous after a certain period of time to form a representative part of a substance specimen. Substance volume units are formed in these channel sections. The lengths of the volume units are determined exclusively by the lengths of the channel sections. Pulse-shaped substance volume sequences are injected into the separation channel. The signal-to-noise ratio of the measurement results is substantially improved by generating substance volume sequences on the basis of pseudo-randomly scattered binary digit sequences similar to Hadamard sequences, and by a cross-correlation analysis of spectra measured on the basis of such substance volume sequences.
Microfluidic microchip for the chemical, physical, and/or biological analysis or synthesis of substances, with a channel structure, wherein the substances are capable of moving, in accordance with the channel structure, under the imposition of an electrical potential, comprising
Microfluidic microchip for the chemical, physical, and/or biological analysis or synthesis of substances, with a channel structure, wherein the substances are capable of being moved, in accordance with the channel structure under the imposition of an electrical potential,
A method of operating a microfluidic microchip in a chemical, physical and/or biological analyzer or synthesizer of a substance, the microfluidic microchip including a channel structure having a delivery channel and a leading channel, the substance being of a type that moves in the channel structure in response to a potential being imposed thereon, the method comprising applying a temporally substantial constant potential to the substance while the substance is in the delivery channel to cause substantially continuous, uninterrupted movement of the substance in the delivery channel toward the leading channel, and applying a pseudo-random modulated signal to the substance while the substance is in the leading channel to cause pseudo-random modulated movement of the substance in the leading channel, the analyzer or synthesizer being responsive to the substance undergoing the pseudo-random modulated movement.
Dependencies are inferred from the claim text.