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US 6,491,940 B1Granted
Apparatus for administering composition for inhibiting cerebral neurovascular disorders and muscular headaches
OwnerBruce H. Levininventor
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OwnerBruce H. Levininventor
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Methods, kits, apparatus, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition and an intranasal applicator and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention. Apparatus for delivering or applying the compositions of the invention or for performing the methods of the invention are also described.
A dorsonasal drug delivery device comprising a body having a shape which conforms to the shape of the nasal cavity of a human, the body having a proximal end and a distal portion having a distal end, the distal portion being curved or angled with respect to a longitudinal axis of the body, the longitudinal axis of body at the distal end forming an angle of about 90 degrees to about 170 degrees with respect to the longitudinal axis at the proximal end prior to insertion of the distal end into the nasal cavity, such that when the distal portion of the body is in the apex of the nasal cavity, the distal end faces a posterior portion of the nasal cavity for dorsonasal delivery of the drug, and wherein the distal portion can be urged through a nostril of the human into the apex of the nasal cavity without injuring the human.
A method of dorsonasally administering a composition to a human patient, the method comprising
A method of dorsonasally administering a composition to a human patient, the method comprising
A method of dorsonasally administering a composition to a human patient, the method comprising
An anatomically adapted dorsonasal delivery nozzle for dorsonasally administering a composition to a human patient, the nozzle comprising a body having
A method of dorsonasally administering a composition to a human patient, the method comprising
In a manually pressure-actuated drug delivery device comprising an intranostril applicator for insertion into a nostril of a patient, a drug container, and a manually pressure-actuated actuator fixed to at least one of the applicator and the container and actuatably fluidly connecting the applicator and the container, whereby the drug from the container is provided to the applicator upon application of pressure by the patient to the actuator,
In a manually pressure-actuated drug delivery device comprising a body having an intranostril applicator for insertion into a nostril of a patient, a drug container, and a manually pressure-actuated actuator fixed to at least one of the applicator and the container and actuatably fluidly connecting the applicator and the container, whereby drug from the container is provided to the applicator upon application of pressure by the patient to the actuator,
A systemic drug delivery device comprising a body having a shape which conforms to the shape of the nasal cavity of a human, the body having a proximal end and a distal portion which can be urged through a nostril of the human into the apex of the nasal cavity without injuring the human, the distal portion having a distal end and being curved or angled with respect to a longitudinal axis of the body, the longitudinal axis of body at the distal end forming an angle of about 90 degrees to about 170 degrees with respect to the longitudinal axis at the proximal end prior to insertion of the distal end into the nasal cavity, such that when the distal portion of the body is in the apex of the nasal cavity, the distal portion faces a posterior portion of the nasal cavity for dorsonasal delivery of the drug, wherein the body has an applicator portion in the form of at least one of
An anatomically adapted intranasal delivery nozzle for systemically administering a composition to a human patient, the nozzle comprising a body having
Dependencies are inferred from the claim text.