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US 6,488,896 B2Granted
Microfluidic analysis cartridge
AssigneeMicronics, Inc.
InventorsBernhard H. Weigl, Gerald L. Klein, Ronald L. Bardell, Clinton L. Williams, Thomas H. Schulte
Life of this patent
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Abstract
A device for analyzing sample solutions such as whole blood based on coagulation and agglutination which requires no external power source or moving parts to perform the analysis. Single disposable cartridges for performing blood typing assays can be constructed using this technology.
Claims15
A microfluidic device for analyzing fluids, comprising:
- a body structure;
- means located within said body structure for introduction of a sample fluid and a reagent fluid;
- a flow channel having a first end, coupled to said introduction means, and a second end, for allowing flowing contact between said sample fluid and said reagent fluid along said flow channel such that a reaction between said fluids can occur, with said reaction causing formation of particles within said flow channel into visibly detectable clusters;
- and
- separation means, coupled to said second end of said flow channel, having varying dimensions to separate particle clusters of differing sizes.
2 more elements
A microfluidic device for analyzing blood, comprising:
- a body structure;
- means located within said body structure for introduction of a whole blood sample and a reagent sample;
- a whole blood sample;
- a reagent sample containing a specific blood type antiserum;
- and a flow channel having a first end, coupled to said introduction means, and a second end, for allowing flowing contact between said whole blood sample and said reagent sample along said flow channel such that a reaction between said samples can occur, with said reaction causing formation within said flow channel of visibly detectable clusters;
- wherein the presence of visibly detectable clusters within said flow channel indicates that the blood type of said blood sample matches the specific blood type antiserum within said reagent sample.
3 more elements
Dependencies are inferred from the claim text.