Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation

A method of performing in-vivo sonoporation of a skin area and transdermal and/or intradermal delivery of a drug solution comprising:

• providing a container containing a predetermined amount of said drug solution and having a first end and a second end, said second end being covered with a porous membrane;
• submerging a tip of an ultrasound horn in said drug solution through said first end of the container;
• placing said porous membrane in contact with said skin area;
• and
• applying ultrasound radiation to said drug solution wherein said ultrasound radiation has a frequency in the range of 15 KHz and 1 MHz and is applied at an intensity, for a period of time and at a distance from said skin area effective to generate cavitation bubbles, wherein said cavitation bubbles collapse and transfer their energy into the skin area thus causing the formation of pores in the skin area;
• and wherein said ultrasound radiation intensity and distance from the skin area are also effective in generating ultrasonic jets, said ultrasonic jets driving said drug solution through said porous membrane and said formed pores into the skin area.