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US 6,486,672 B1Granted
High-resolution NMR spectroscopy of molecules encapsulated in low-viscosity fluids
OwnerA. Joshua Wand, Mark R. Ehrhardt +1inventors
InventorsA. Joshua Wand, Mark R. Ehrhardt, Peter F. Flynn
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Abstract
The present invention provides a method for reducing the correlation time for global tumbling for analysis of proteins and other macromolecules by NMR spectroscopy. The method comprises placing a macromolecule, hydrated and without significant structure perturbation, within a reverse micelle in a suitable fluid medium of low viscosity. A high pressure NMR cell for use with the method of the present invention is also disclosed.
Claims3
A Pressure cell for use in NMR spectroscopy of molecules comprising:
- (a) a sample tube;
- (b) a housing for holding the sample tube;
- and
- (c) a cover for closing the housing, said cover, having at least one opening for inflow of fluid and at least one opening for outflow of fluid,
- wherein the sample tube self-seals under pressure against the housing and wherein the cover self-seals under pressure against the housing.
2 more elements
Dependencies are inferred from the claim text.