Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins

An isolated mouse cell line, which is homozygous for a first disruption in a gene encoding retinoid X receptor-β (RXRβ), wherein said first disruption comprises insertion of an exogenous DNA in a region encoding a DNA binding domain, and wherein said first disruption prevents normal expression of said gene, and which is homozygous or heterozygous for a second disruption in a gene encoding retinoid X receptor-α (RXRα), wherein said second disruption prevents normal expression of said RXRα gene.

An isolated mouse cell line, which is heterozygous for a first disruption in a gene encoding retinoid X receptor-β (RXRβ), wherein said first disruption comprises insertion of an exogenous DNA in a region encoding a DNA binding domain, and wherein said first disruption prevents normal expression of said gene, and which is homozygous or heterozygous for a second disruption in a gene encoding retinoid X receptor-α (RXRα), wherein said second disruption prevents normal expression of said RXRα gene.

A mouse cell, wherein the genome of the cell comprises a disruption in exon 4 of the gene encoding retinoid X receptor-α (RXRα).