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US 6,486,345 B1Granted
Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters
AssigneeLonza Ltd.
InventorJosef Schröer
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Abstract
A method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I), wherein the dianion of an acetoacetic acid alkyl ester is reacted with an aldehyde. The 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I) are important synthesis building blocks for producing HMG-CoA-reductase-inhibitors.
Claims6
A process for preparing a 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid ester of formula:
- in which R1 and R2 are identical or different and are C1-6-alkyl, comprising reacting an alkyl acetoacetate of formula:
- in which R1 is a defined above, in the presence of a base with an aldehyde of formula:
- in which R2 is as defined above.
Dependencies are inferred from the claim text.