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US 6,486,342 B1Granted
Substituted chiral allosteric hemoglobin modifiers
AssigneeVirginia Commonwealth University
InventorsDonald J. Abraham, Gajanan S. Joshi, Stephen J. Hoffman, Melissa Grella, Richmond Danso-Danquah, Amal Yousseff, Martin Safo, Sanjeev Kulkarni
Life of this patent
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Abstract
A family of substituted chiral allosteric effectors of hemoglobin is useful for delivering more oxygen to hypoxic and ischemic tissues by reducing the oxygen affinity of hemoglobin in whole blood.
Claims16
A compound having the formula:
- wherein:
- R1-10 are selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkoxy, a carbon ring connecting any two of R1-R5, and a halogen;
- and at least one of R6-R10 is substituted with a moiety having the formula:
- wherein:
- R11 and R12 are part of a cyclic ring connecting R11 and R12 where the cyclic ring is selected from the group consisting of alkyl substituted five member ring, alkyl substituted six member ring, alkyl substituted heteroatom five member ring, and heteroatom six member ring;
- and
- R13 is selected from the group consisting of hydrogen, inorganic cation, organic cation, metal cation, and ammonium cation.
4 more elements
A purified negative isomer having the formula:
- wherein:
- R1-10 are selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkoxy, a carbon ring connecting any two of R1-R5, and a halogen;
- and at least one of R6-R10 is substituted with a moiety having the formula:
- R11 and R12 are part of a cyclic ring connecting R11 and R12 where the cyclic ring is selected from the group consisting of five member ring, alkyl substituted five member ring, six member ring, alkyl substituted six member ring, alkyl substituted heteroatom five member ring, heteroatom five member ring, and heteroatom six member ring;
- and
- R13 is selected from the group consisting of hydrogen, inorganic cation, organic cation, metal cation, and ammonium cation.
3 more elements
Dependencies are inferred from the claim text.