Method for producing hydroxymethylpyridines
AssigneeDSM Fine Chemicals Austria NFG GmbH & Co KG
InventorsKarlheinz Giselbrecht, Rudolf Hermanseder
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Abstract
The invention relates to a method for producing hydroxymethylpyridines from the corresponding vinylpyridines by means of ozonisation in an alcohol as solvent and by means of hydrogenation of the peroxide-containing solution produced thereby, in the presence of a hydrogenation catalyst The hydrogenation solution is adjusted to a pH value of 10 to 14 by adding a base and the alcohol is distilled off and the desired hydroxymethylpyridine is isolated in high purity by extracting with an organic solvent and by means of subsequent distillative purification.
Claims9
A process for preparing hydroxymethylpyridines which comprises
- a) subjecting the corresponding vinylpyridine to ozonolysis in an alcohol solvent and hydrogenating the resulting peroxidic solution in the presence of a hydrogenation catalyst,
- b) adjusting the hydrogenation solution by addition of a base to a pH of from 10 to 14 and distilling off the alcohol, and then
- c) isolating the desired hydroxymethylpyridine in high purity by extraction with an organic solvent and subsequent distillative purification.
Dependencies are inferred from the claim text.