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US 6,486,307 B1Granted
Preparation of glucosamine hydrochloride
AssigneeAlberta Research Council
InventorsNeena Gandhi, James Kenneth Laidler
Life of this patent
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Abstract
A method of producing glucosamine hydrochloride from chitin by grinding the chitin to a very fine size and digestion with concentrated hydrochloric acid. The glucosamine hydrochloride is decolorized with activated charcoal, washed with ethanol and assayed by pH titration with a base.
Claims14
A method of producing glucosamine hydrochloride from chitin or chitinaceous material, said method comprising the steps of:
- (a) grinding the chitin or chitinaceous material to less than about −20 mesh;
- (b) digesting the chitin with prewarmed, concentrated HCl, by mixing the chitin with the HCl, and heating to about 95° C. to produce a slurry;
- (c) cooling the slurry to room temperature and filtering the precipitate;
- (d) dissolving the precipitate in water and with activated charcoal at room temperature;
- (e) filtering the solution and discarding the solids;
- (f) evaporating the solution to recover GHCl solids;
- (g) washing the solids with ethanol and filtering the solids/ethanol mixture to separately recover both the solids and the ethanol;
- and
- (h) drying the solids.
6 more elements
A method of producing glucosamine hydrochloride from chitin or chitinaceous material, said method comprising the steps of:
- (a) hydrolysing the chitin in hydrochloric acid;
- (b) precipitating the glucosamine hydrochloride;
- (c) separating the precipitated glucosamine hydrochloride and redissolving it in water;
- and
- (d) assaying for GHCl by pHmetric titration.
2 more elements
Dependencies are inferred from the claim text.