Filtration

A filtration method for removing at least one virus selected from the group consisting of hepatitis virus A, polio virus and parvo virus from a solution containing at least one macromolecule, comprising virus-filtering the solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation with the salt, and wherein the salt is selected from the group consisting of sodium chloride, potassium chloride, sodium acetate, sodium citrate, sodium phosphate, potassium dihydrophosphate and combinations thereof.

A filtration method for removing at least one virus selected from the group consisting of hepatitis virus A, polio virus and parvo virus from a solution containing at least one macromolecule, comprising virus-filtering the solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation with the salt, and wherein the macromolecule is in solution during the virus filtering.

A method for obtaining parvo virus, comprising filtering a solution containing the virus, at least one macromolecule, and a salt, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation of the solution with the salt and the macromolecule is in solution during the filtering step.

A method for obtaining polio virus for use in a vaccine, comprising filtering a solution containing the virus, at least one macromolecule, and a salt, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation of the solution with the salt and the macromolecule is in solution during the filtering step.

A filtration method comprising virus-filtering a solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M to 2 M and the virus-filtering step employs dead-end filtration.

A filtration method, comprising virus-filtering a solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.6 M to 2 M.

A filtration method for virus-filtering a solution containing at least one macromolecule selected from the group consisting of factor VIII, factor IX, antithrombin III, human serum albumin, gammaglobulin, streptokinase, apolipoproteins, and growth hormones, comprising virus-filtering the solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M to 2 M.

A filtration method for virus-filtering a solution containing at least one macromolecule selected from the group consisting of factor VIII, factor IX, antithrombin III, human serum albumin, gammaglobulin, streptokinase, apolipoproteins, and growth hormones, comprising virus-filtering the solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation with the salt, and wherein the salt is selected from the group consisting of sodium chloride, potassium chloride, sodium acetate, sodium citrate, sodium phosphate, potassium dihydrophosphate and combinations thereof.

A filtration method for virus-filtering a solution containing at least one macromolecule selected from the group consisting of factor VIII, factor IX, antithrombin III, human serum albumin, gammaglobulin, streptokinase, apolipoproteins, and growth hormones, comprising virus-filtering the solution containing at least one macromolecule, wherein the total salt content of the solution is within the range of from about 0.2 M up to saturation with the salt, and wherein the macromolecule is in solution during the virus filtering.