Interleukin-20
AssigneeHuman Genome Sciences, Inc.
InventorsReinhard Ebner, Marianne Murphy, Steven M. Ruben, Jing-Shan Hu, D. Roxanne Duan, Kimberly A. Florence, Craig A. Rosen
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Abstract
The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
Claims18
An isolated polypeptide consisting of a member selected from the group consisting of:
- (a) a polypeptide set forth as amino acid residues −20 to 160 of SEQ ID NO:2;
- (b) a polypeptide set forth as amino acid residues −19 to 160 of SEQ ID NO:2;
- (c) a polypeptide set forth as amino acid residues 1 to 160 of SEQ ID NO:2;
- (d) a polypeptide set forth as amino acid residues 2 to 160 of SEQ ID NO:2;
- (e) a polypeptide set forth as amino acid residues 3 to 160 of SEQ ID NO:2;
- (f) a polypeptide set forth as amino acid residues 4 to 160 of SEQ ID NO:2;
- (g) a polypeptide set forth as amino acid residues 5 to 160 of SEQ ID NO:2;
- (h) a polypeptide set forth as amino acid residues 6 to 160 of SEQ ID NO:2;
- (i) a polypeptide set forth as amino acid residues 7 to 160 of SEQ ID NO:2;
- (j) a polypeptide set forth as amino acid residues 8 to 160 of SEQ ID NO:2;
- (k) a polypeptide set forth as amino acid residues 9 to 160 of SEQ ID NO:2;
- (l) a polypeptide set forth as amino acid residues 10 to 160 of SEQ ID NO:2;
- (m) a polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209232;
- (n) a polypeptide, excluding the N-terminal methionine residue, having the amino acid sequence encoded by the cDNA clone contained in ATCC Deposit No. 209232;
- and
- (o) a polypeptide having the amino acid sequence of a mature polypeptide encoded by the cDNA clone contained in ATCC Deposit No. 209232.
Dependencies are inferred from the claim text.