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AssigneeCambridge Scientific, Inc.
InventorsDonald L. Wise, Joseph D. Gresser, Debra J. Trantolo, Yung-Yueh Hsu
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A bioerodible polymeric material, and in particular a semi-interpenetrating network (“semi-IPN”) alloy, is disclosed. A beneficial end use of this material is in the form of internal fixation devices (IFDs) (such as bone supports, plates, and pins) and as cured bone cements for bone repair. A multi-part bioerodible cement system, which, upon mixing of the system parts, forms a cured bioerodible cement, includes, in one part, a first bioerodible polymer (e.g., PLGA) capable of producing acidic products upon hydrolytic degradation, and, in another part, a second bioerodible scaffolding polymer (e.g., PPF) which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for the cured cement. In another aspect, a bone cement system of the invention includes a bioerodible scaffolding polymer (such as PPF), which when polymerized provides a hardened bone cement, the cement system further including a gas generating agent in stabilized form for providing the cured bone cement with pores for facilitating inward cell migration.
A multi-part bioerodible bone cement system comprising two or more separate parts which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, wherein a first said part comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation and one of said parts, which may be the same as or different from said first part, comprises a second bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy;
A multi-part bioerodible bone cement system comprising two or more separate parts which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, wherein a first said part comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation and one of said parts, which may be the same as or different from said first part, comprises a second bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy;
A bioerodible bone cement system, the shelf-stability of which is maintained at a temperature which is below the freezing points of the components of the system and which, upon raising of the temperature of the system, forms a bioerodible polymeric semi-IPN alloy, said system comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, a second bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, a crosslinking initiator and a crosslinking agent for said second bioerodible scaffolding polymer, wherein said system further comprises a therapeutically effective amount of a biologically active or therapeutic agent in a protective coating of a bioerodible polymer.
A bioerodible bone cement system, the shelf-stability of which is maintained at a temperature which is below the freezing points of the components of the system and which, upon raising of the temperature of the system, forms a bioerodible polymeric semi-IPN alloy, said system comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, a second bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, a crosslinking initiator and a crosslinking agent for said second bioerodible scaffolding polymer, wherein said system further comprises a gas generating agent in stabilized form.
A multi-part bioerodible bone cement system comprising two or more separate parts which, upon mixing of the system parts, forms a bioerodible polymeric bone cement, wherein one of said parts comprises a bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said bone cement;
A multi-part bioerodible bone cement system comprising two or more separate parts which, upon mixing of the system parts, forms a bioerodible polymeric bone cement, wherein one of said parts comprises a bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said bone cement;
A bioerodible bone cement system, the shelf-stability of which is maintained at a temperature which is below the freezing points of the components of the system and which, upon raising of the temperature of the system, forms a bioerodible polymeric bone cement, said system comprising a bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said polymeric bone cement, a crosslinking initiator and a crosslinking agent for said bioerodible scaffolding polymer, wherein said system further comprises a therapeutically effective amount of a biologically active or therapeutic agent in a protective coating of a bioerodible polymer.
A bioerodible bone cement system, the shelf-stability of which is maintained at a temperature which is below the freezing points of the components of the system and which, upon raising of the temperature of the system, forms a bioerodible polymeric bone cement, said system comprising a bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said polymeric bone cement, a crosslinking initiator and a crosslinking agent for said bioerodible scaffolding polymer, wherein said system further comprises a gas generating agent in stabilized form.
A method of making a foaming, bioerodible, polymeric bone cement, said cement comprising a crosslinked bioerodible scaffolding polymer, said crosslinked polymer providing a biopolymeric scaffolding or internal reinforcement for said polymeric bone cement, said method comprising the steps of:
A method of making a foaming, bioerodible, polymeric semi-IPN alloy bone cement, said cement comprising a bioerodible polymer capable of producing acidic products upon hydrolytic degradation and a crosslinked bioerodible scaffolding polymer, said crosslinked polymer providing a biopolymeric scaffolding or internal reinforcement for said polymeric semi-IPN alloy bone cement, said method comprising the steps of:
Dependencies are inferred from the claim text.