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US 6,486,214 B1Granted
Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
AssigneeRutgers, The State University of New Jersey
InventorKathryn E. Uhrich
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Abstract
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drugs to a host via the polymeric drug delivery systems.
Claims3
A polyanhydride comprising repeating units of Formula (1):
- wherein
- R1 is a low molecular weight drug molecule comprising a carboxylic acid group and at least one amine, thiol, alcohol or phenol group;
- X is selected from the group consisting of amides, thioamides, esters and thioesters;
- and
- R2 is an alkyl represented by —(CH2)n, wherein n is from 1 to 20.
2 more elements
Dependencies are inferred from the claim text.