Sustained release, and comfortable opthalmic composition and method for ocular therapy
AssigneeAlcon Laboratories, Inc.
InventorsErnesto J. Castillo, Ruma Sarkar, Onkar N. Singh, Alan L. Weiner, Cody Yarborough
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Abstract
This invention relates to reduced stinging, sustained release ophthalmic formulations and the method of treatment comprising administering such formulations topically to the eye when in need thereof.
Claims33
An ophthalmic composition, comprising:
- a) at least one basic active;
- b) a polyanionic polymer;
- c) an ion exchange resin;
- and
- d) a pH adjusting agent, wherein said agent is present in an amount sufficient to adjust the pH of the composition to between about 3.5 and about 9.5 and wherein the pH adjusting agent is a basic amine and does not substantially disrupt interaction between the basic active and the ion exchange resin.
An opthalmic composition comprising:
- levobetaxolol hydrochloride;
- poly(styrene divinylbenzene) sulfonic acid;
- carbomer;
- mannitol;
- boric acid;
- disodium edetate;
- benzalkonium chloride;
- N-lauroylsarcosine;
- and
- tromethamine, and optionally hydrochloric acid, in an amount sufficient to adjust the pH of the composition to between about 6.5.
A method of treating an eye in need thereof, which comprises administering topically to an affected eye, an ophthalmic composition comprising:
- a) at least one basic active;
- b) a polyanionic polymer;
- c) an ion exchange resin;
- and
- d) a pH adjusting agent, wherein said agent is present in amount sufficient to adjust the pH of the composition to between about 3.5 and about 9.5;
- and wherein the pH adjusting agent is a basic amine and does not substantially disrupt interaction between the basic active and the ion exchange resin.
The method according to claim 33, wherein said betaxolol is levobetaxolol, and said prostaglandin analog is cloprostenol, fluprostenol, latanoprost, or travoprost.
The composition according to claim 33, wherein said prostaglandin analog is travoprost.
Dependencies are inferred from the claim text.