Mechanical and pharmacologic therapies to treat cardiac arrest
AssigneeCPRx LLC
InventorKeith G. Lurie
Life of this patent
Estimating the term…
Abstract
A method for resuscitating a patient from cardiac arrest, comprising: (a) administering CPR, and (b) administering: i) an amount of one or more vasopressor agents, or one or more vasopressinergic agonists, or a combination thereof, sufficient to increase the patient's arterial blood pressure; and ii) an amount of L-arginine, nitric oxide, a direct nitric oxide donor, or another nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to the patient's brain and heart, as well as kits and pharmaceutical compositions useful for practicing the method are described.
Claims28
A method for resuscitating a patient from cardiac arrest, comprising:
- (a) administering cardiopulmonary resuscitation (“CPR”), and (b) administering:
- i) an amount of one or more vasopressor agents, or one or more vasopressinergic agonists, or a combination thereof, sufficient to increase the patient's arterial blood pressure;
- and ii) an amount of L-arginine, nitric oxide, or a direct nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to the patient's brain and heart.
A kit for the treatment of cardiac arrest comprising packaging material containing:
- a) an amount of one or more vasopressor agents, or one or more vasopressinergic agonists, or a combination thereof, sufficient to increase a patient's arterial blood pressure;
- b) an amount of L-arginine, nitric oxide, or a direct nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to a patient's brain and heart;
- and c) instruction means indicating that the compounds described in a) and b) are to be administered to a patient undergoing cardiopulmonary resuscitation.
A pharmaceutical composition comprising:
- a) an amount of one or more vasopressor agents, or one or more vasopressinergic agonists, or a combination thereof, sufficient to increase arterial blood pressure;
- b) an amount of L-arginine, nitric oxide, or a direct nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to the brain and heart;
- and c) a pharmaceutically acceptable carrier.
A method for resuscitating a patient from cardiac arrest, comprising:
- (a) administering cardiopulmonary resuscitation (“CPR”), and (b) administering:
- I) an amount of one or more vasopressor agents, and one or more vasopressinergic agonists, sufficient to increase the patient's arterial blood pressure;
- and ii) an amount of L-arginine, nitric oxide, or a direct nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to the patient's brain and heart.
A method for resuscitating a patient from cardiac arrest, comprising:
- (a) administering cardiopulmonary resuscitation (“CPR”), and (b) administering:
- I) an amount of one or more vasopressinergic agonists sufficient to increase the patient's arterial blood pressure;
- and ii) an amount of L-arginine, nitric oxide, or a direct nitric oxide donor, or a combination thereof, sufficient to enhance arterial blood flow to the patient's brain and heart.
Dependencies are inferred from the claim text.