US 6,486,205 B2 · Mixture of primary fatty acids obtained from sugar cane wax

Abstract

A new natural mixture of primary fatty acids of high molecular weight ranging from 24 to 38 carbon atoms, especially those ranging between 26 and 36 carbon atoms and more especially those of straight chain of 26, 28, 29, 30, 31, 32, 33, 34, 35 and 36 carbon atoms. This mixture has a relative composition of each fatty acid that is highly reproducible batch to batch and it is extracted from sugar cane (Saccharum officinarum, L.) wax. This mixture of fatty acids has specific pharmacological properties that supports its use as an active component of pharmaceutical formulations used as hypocholesterolemic and against hypercholesterolaemia type II, as antiplatelet, anti-thrombotic and anti-ischemic. This mixture of primary fatty acids is also effective in the inhibition of the development of gastric ulcers induced by different agents.

Claims19

Dependent claims

A pharmaceutically beneficial composition of primary fatty acids consisting of a mixture of:

(a) 1-hexacosanoic acid;
(b) 1-octacosanoic acid;
(c) 1-nonacosanoic acid;
(d) 1-triacontanoic acid;
(e) 1-hentriacontanoic acid;
(f) 1-dotriacontanoic acid;
(g) 1-tritriacontanoic acid;
(h) 1-tetratriacontanoic acid;
(i) 1-pentatriacontanoic acid;
and,
(j) 1-hexatriacontanoic acid;
wherein said pharmaceutically beneficial composition of primary fatty acids are a natural mixture obtained from a homogeneous saponification of sugar cane wax and substantially free of other fatty acids having 24 to 38 carbon atoms.

9 more elements

A pharmaceutically beneficial composition of primary fatty acids wherein said mixture comprises:

(a) 1-hexacosanoic acid which is about 0.3 to 1.5% of total weight;
(b) 1-octacosanoic acid which is about 25 to 50% of total weight;
(c) 1-nonacosanoic acid which is about 1 to 3% of total weight;
(d) 1-triacontanoic acid which is about 15 to 30% of total weight;
(e) 1-hentriacontanoic acid which is about 0.8 to 3% of total weight;
(f) 1-dotriacontanoic acid which is about 10 to 22% of total weight;
(g) 1-tritriacontanoic acid which is about 1 to 3% of total weight;
(h) 1-tetratriacontanoic acid which is about 10 to 22% of total weight;
(i) 1-pentatriacontanoic acid which is about 0.5 to 1.5% of total weight;
and,
(j) 1-hexatriacontanoic acid which is about 2 to 9% of total weight wherein said pharmaceutically beneficial composition of primary fatty acids is a natural mixture obtained from a homogeneous saponification of sugar cane.

8 more elements

A method for obtaining a pharmaceutically beneficial composition of primary fatty acids mixture as free acids or in form of their salt from sugar cane wax comprising the steps of:

saponifying sugar cane wax with a concentrated hydroxide solution for at least 30 minutes wherein said concentrated hydroxide solution is selected from the group consisting of alkalines and earth alkalines;
isolating said fatty acid mixture from the rest of the components of said homogeneous saponification of sugar cane wax by extracting said components from said saponified wax using a solid-liquid extraction system, wherein said solid-liquid extraction system uses an extraction solvent wherein said extraction solvents are selected from the group consisting of ketones having 3 to 8 carbon atoms, alcohols having 1 to 5 carbon atoms, hydrocarbons having 5 to 8 carbon atoms, haloforms, aromatic compounds, mixtures and aqueous solutions thereof;
purifying the mixture by successive recrystallizations wherein successive recrystallizations are preformed in a recrystallization solution wherein said recrystallization solution is selected from the group consisting of ketones having 3 to 8 carbon atoms, alcohols having 1 to 5 carbon atoms, hydrocarbons having 5 to 8 carbon atoms, aromatic compounds, mixtures thereof, aqueous solutions thereof and water;
refluxing the components in an adequate reflux solvent wherein said reflux solvents are selected from the group consisting of ketones having 3 to 8 carbon atoms, alcohols having 1 to 5 carbon atoms, hydrocarbons having 5 to 8 carbon atoms, aromatic compounds, mixtures and aqueous solutions thereof;
hot filtering immediately thereafter the mixture;
and,
regenerating the mixture using a regeneration solution wherein said regeneration solution is selected from the group consisting of organic acids, mineral acids, and combinations thereof wherein the regeneration produces the mixture comprising:
(a) 1-hexacosanoic acid;
(b) 1-octacosanoic acid;
(c) 1-nonacosanoic acid;
(d) 1-triacontanoic acid;
(e) 1-hentriacontanoic acid;
(f) 1-dotriacontanoic acid;
(g) 1-tritriacontanoic acid;
(h) 1-tetratriacontanoic acid;
(i) 1-pentatriacontanoic acid;
and,
(j) 1-hexatriacontanoic acid.

15 more elements

Dependencies are inferred from the claim text.

Mixture of primary fatty acids obtained from sugar cane wax

Life of this patent

Mixture of primary fatty acids obtained from sugar cane wax

Life of this patent

Abstract

Claims19