Inhibitors of isoprenyl transferase

A pharmaceutical composition comprising a compound selected from the group consisting of

• or pharmaceutically acceptable salts thereof;
• and one or more pharmaceutically acceptable excipients.

A method for treating ras-related tumors in a mammal in need of such treatment which comprises administering an effective amount for treating said tumor of a compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof.

A method for treating ras-related tumors in a mammal in need of such treatment which comprises administering an effective amount for treating said tumor of a pharmaceutical composition comprising a compound selected from the group consisting of

• or pharmaceutically acceptable salts thereof;
• and one or more pharmaceutically acceptable excipients.

A method for treating ras-related tumors in a mammal in need of such treatment which comprises administering a first amount of paclitaxel and a second amount of a compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof;
• said first amount of said paclitaxel and said second amount of said compound being effective, in combination, to treat said tumor.

A method for treating ras-related tumors in a mammal in need of such treatment which comprises administering a first amount of paclitaxel and a second amount of a pharmaceutical composition comprising a compound selected from the group consisting of

• or pharmaceutically acceptable salts thereof;
• and one or more pharmaceutically acceptable excipients;
• said first amount of said paclitaxel and said second amount of said pharmaceutical composition being effective, in combination, to treat said tumor.