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US 6,486,192 B1Granted
Indole compounds useful for treating bacterial infections
AssigneeSmithKline Beecham Corporation
InventorsRobert A. Daines, Pamela A. Chambers
Life of this patent
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Abstract
This invention relates to the use of certain indole compounds, which are active as inhibitors of the fatty acid synthase FabH, for the treatment of bacterial infections.
Claims3
A method of treating bacterial infections by administering to a patient in need thereof an effective amount of a compound of Formula (I):
- wherein:
- R1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, C1-10 alkyl, cycloalkyl, arylalkyl, heteroarylalkyl and heterocyclicalkyl;
- R2 is selected from the group consisting of aryl, substituted aryl, and heteroaryl;
- R3 is selected from the group consisting of H, lower alkyl, CHO, and COR4;
- R4 is selected from the group consisting of aryl, substituted aryl, heteroaryl, and C1-10 alkyl;
- n is an integer selected from the group consisting of 0, 1, and 2;
- and
- Y is selected from the group consisting of CH2, NR3, O, and S;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.