N-[4-(heteroarylmethyl)phenyl]-heteroarylamines

A compound of formula

• a N-oxide, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein:
• R1 represents hydrogen, hydroxy, C1-6alkyl or aryl;
• R2 represents hydrogen;
• C1-12alkyl;
• C3-7cycloalkyl;
• C2-8alkenyl;
• aryl;
• pyrrolidinyl optionally substituted with C1-4alkyl or C1-4alkyloxycarbonyl;
• or C1-12alkyl substituted with one or two substituents selected from C3-7cycloalkyl, hydroxy, C1-4alkyloxy, cyano, amino, mono- and di(C1-4alkyl)amino, mono- and di(aryl)amino, arylC1-4alkylamino, (C1-4alkyl)(arylC1-4alkyl)amino, or pyrrolidinyl;
• R3 represents hydrogen, C1-6alkyl, aryl or C1-6alkyl substituted with aryl;
• Het represents an unsaturated heterocycle selected from imidazolyl or triazolyl;
• each of said unsaturated heterocycles may optionally be substituted with amino, mercapto, C1-6alkyl, C1-6alkylthio or aryl;
• represents a radical of formula
• wherein each X independently represents NR8 or O;
• wherein R8 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl;
• R4 and R5 each independently represent hydrogen, hydroxy, halo, cyano, nitro, amino, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, C1-6alkyloxy, formyl, carboxyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl or aryl;
• —R6—R7— represents a bivalent radical of formula:
• —CR9=CR9—CR9=CR9— (b-1);
• wherein each R9 independently represents hydrogen, hydroxy, halo, nitro, amino, C1-6alkyl,
• hydroxyC1-6alkyl, haloC1-6alkyl, C1-6alkyloxy, formyl, carbocyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl or aryl;
• and
• aryl represents phenyl or phenyl substituted with one, two or three substituents selected from hydroxy, halo, cyano, amino, mono- or di(C1-6alkyl)amino, C1-6alkyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkyloxy, formyl, carboxyl and C1-6alkylcarbonyl;
• or two adjacent carbon atoms on said phenyl may be substituted by a single bivalent radical having the formula C1-12alkanediyl or haloC1-12alkanediyl.