Mutual prodrugs of amlodipine and atorvastatin
AssigneePfizer Inc.
InventorsGeorge Chang, Ernest S. Hamanaka, John L. LaMattina
Life of this patent
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Abstract
This invention relates to mutual prodrugs of amlodipine and atorvastatin and to pharmaceutical compositions thereof. This invention also relates to methods of treating angina pectoris, atherosclerosis, and hypertension and hyperlipidemia in a mammal using those prodrugs and compositions. This invention also relates to methods of managing cardiac risk in a mammal, including humans, presenting with symptoms of cardiac risk by administering those prodrugs and compositions.
Claims47
A compound which is a mutual prodrug of amlodipine and atorvastatin or a pharmaceutically acceptable salt thereof.
4-(2-Chloro-phenyl)-2-(2-[(5-{7-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoyloxymethyl}-2-oxo-[1,3]dioxol-4-ylmethyl)-amino]-ethoxymethyl}-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethylester 5-methyl ester.
4-(2-Chloro-phenyl)-2-(2-{7-[2-(4-fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoyloxymethoxycarbonylamino}-ethoxymethyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester.
Dependencies are inferred from the claim text.