Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
AssigneeCity of Hope
InventorsJerry L. Nadler, Rama Natarajan
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Abstract
The present invention relates to a method for inhibiting the etiology of disease in patients having a disease state caused by an excess of 12-lipoxygenase or its products. In particular, the invention provides for administration of a human leukocyte 12-lipoxygenase pathway inhibitor to inhibit disease etiology, to inhibit the proliferation of breast cancer and to increase insulin receptor phosphorylation in a patient having Type II diabetics.
Claims1
A method for treating breast cancer by inhibiting or reducing vascular endothelial growth factor production in a non-diabetic human patient which comprises administering to said patient pioglitazone in an amount effective to retard or inhibit the expression of hl 12-lipoxygenase.
Dependencies are inferred from the claim text.