Indane derivatives

Indane compounds of formula (I):

• wherein
• R1 represents hydrogen atom, halogen atom, C1-6 alkyl group (said alkyl group is unsubstituted or substituted by halogen atom, carboxyl group, C1-6 alkoxy group, C2-6 alkoxycarbonyl group, hydroxyl group, formyl group, cyano group or nitro group), C1-6 alkoxy group {said alkoxy group is unsubstituted or substituted by halogen atom, carboxyl group, C2-6 alkoxycarbonyl group, hydroxyl group, phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group), formyl group, cyano group or nitro group}, C3-6 cycloalkyl group {said cycloalkyl group is unsubstituted or substituted by halogen atom, carboxyl group, C2-6 alkoxycarbonyl group, hydroxyl group, C1-6 alkoxy group, phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group), formyl group, cyano group or nitro group}, nitro group, cyano group, formyl group, carboxyl group, hydroxyl group, formamide group, cyanamide group, amino group, C1-6 alkylamino group, di C1-6 alkylamino group (said alkylamino group and di C1-6 alkylamino group is unsubstituted or substituted by halogen atom, carboxyl group, C2-6 alkoxycarbonyl group, hydroxyl group, formyl group, cyano group or nitro group), C1-6 alkylcarbonylamino group, C1-6 alkylsulfonylamino group, aminocarbonyl group, C1-6 alkylaminocarbonyl group, di C1-6 alkylaminocarbonyl group, C1-6 alkylcarbonyl group, C1-6 alkoxycarbonyl group, C1-6 alkylcarbonyloxy group, C1-6 alkylurea group, C1-6 alkylthiourea group, aryl C1-6 alkylamino group, di(aryl C1-6 alkyl)amino group, arylcarbonylamino group, aryl C1-6 alkylcarbonylamino group, arylsulfonylamino group, aryl C1-6 alkylsulfonylamino group, aryl C1-6 alkylaminocarbonyl group, di(aryl C1-6 alkyl)aminocarbonyl group, arylcarbonyl group, aryl C1-6 alkylcarbonyl group, aryloxycarbonyl group, aryl C1-6 alkyloxycarbonyl group, arylcarbonyloxy group, aryl C1-6 alkylcarbonyloxy group, arylurea group, aryl C1-6 alkylurea group, arylthiourea group or aryl C1-6 alkylthiourea group {all of said aryl C1-6 alkylamino group, di(aryl C1-6 alkyl)amino group, arylcarbonylamino group, aryl C1-6 alkylcarbonylamino group, arylsulfonylamino group, aryl C1-6 alkylsulfonylamino group, aryl C1-6 alkylaminocarbonyl group, di(aryl C1-6 alkyl)aminocarbonyl group, arylcarbonyl group, aryl C1-6 alkylcarbonyl group, aryloxycarbonyl group, aryl C1-6 alkyloxycarbonyl group, arylcarbonyloxy group, aryl C1-6 alkylcarbonyloxy group, arylurea group, aryl C1-6 alkylurea group, arylthiourea group and aryl C1-6 alkylthiourea group are unsubstituted or substituted by halogen atom, carboxyl group, C2-6 alkoxycarbonyl group, hydroxyl group, C1-6 alkoxy group, phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group), formyl group, cyano group or nitro group};
• R2 and R3 each independently represent C1-6 alkyl group (said alkyl group is unsubstituted or substituted by halogen atom, C1-6 alkoxy group or hydroxyl group), or R2 and R3 taken together with the carbon atom to which they are bonded form C3-6 cycloalkyl group;
• R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group, or form a bond together with R5, or represents oxygen atom together with R5;
• R5 represents hydrogen atom, or forms a bond together with R4, or represents oxygen atom together with R4;
• R6 represents hydrogen atom, hydroxyl group, C1-6 alkoxy group, C1-6 alkylcarbonyloxy group or NR7R8, wherein
• R7 and R8 taken together represent 1,4-butylene, 1,5-pentylene (said butylene and pentylene are each unsubstituted or substituted by C1-4 alkyl group, phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group), halogen atom, hydroxyl group, C1-4 alkoxy group or C1-6 alkylcarbonyloxy group) or (CH2)1X1(CH2)p (1 and p each mean 1, 2 or 3 while the sum of them becomes 3, 4 or 5;
• X1 represents oxygen atom, sulfur atom or NR14 (R14 is unsubstituted or substituted by hydrogen atom, C1-4 alkyl group or phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group))),
• n means 0 or an integer of 1 to 4;
• X represents C═O;
• Y represents NR17, wherein R17 is hydrogen;
• Z is absent when Y represents NR17;
• W represents
• wherein R9 represents hydrogen atom, halogen atom, C1-6 alkyl group (said alkyl group is unsubstituted or substituted by halogen atom or C1-6 alkoxy group), C1-6 alkoxy group (said alkoxy group is unsubstituted or substituted by halogen atom), phenyl group (said phenyl group is unsubstituted or substituted by halogen atom, hydroxyl group, C1-4 alkyl group or C1-4 alkoxy group), hydroxyl group, nitro group, cyano group, formyl group, formamide group, amino group, C1-6 alkylamino group, di C1-6 alkylamino group, C1-6 alkylcarbonylamino group, C1-6 alkylsulfonylamino group, aminocarbonyl group, C1-6 alkylaminocarbonyl group, di C1-6 alkylaminocarbonyl group, C1-6 alkylcarbonyl group, C1-6 alkoxycarbonyl group, aminosulfonyl group, C1-6 alkylsulfonyl group, carboxyl group or arylcarbonyl group;
• and m is an integer of 1 to 3;
• and R9 may be the same or different when m is 2 or 3;
• or pharmaceutically acceptable salt thereof.