Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
AssigneeCelgene Corporation
InventorsJerome B. Zeldis, Herbert Faleck, Vikram Khetani
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Abstract
In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
Claims46
A method for alleviating fatigue arising from an oncological condition, said method comprising the steps of:
- identifying a patient suffering from said fatigue, and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
A method for alleviating fatigue arising from the administration of a treatment for an oncological condition, said method comprising the steps of:
- identifying a patient suffering from said fatigue, and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
A method for alleviating neurobehavioral slowing arising from an oncological condition, said method comprising the steps of:
- identifying a patient suffering from said neurobehavioral slowing, and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
A method for alleviating neurobehavioral slowing arising from the administration of a treatment for an oncological condition, said method comprising the steps of:
- identifying a patient suffering from said neurobehavioral slowing, and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
A method for alleviating a cognitive side effect of a treatment for an oncological condition, comprising the steps of:
- identifying a patient suffering from a cognitive side-effect of a treatment for an oncological condition;
- and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
A method for treating a symptom of menopause comprising the steps of:
- identifying a patient suffering from a symptom of menpoause;
- and
- administering to said patient a therapeutically effective amount of D-threo-methylphenidate substantially free of the 1-threo isomer.
Dependencies are inferred from the claim text.