Suppression of cyclin kinase 2 activity for prevention and treatment of DNA viral infections
AssigneeBoard of Regents, The University of Texas
InventorsThomas Albrecht, Aubrey E. Thompson, Wade Bresnahan, Laurent Meijer
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Abstract
An important aspect of the present invention is a method for inhibiting proliferation of a DNA virus dependent upon events associated with cell proliferation for replication. The DNA virus includes any of the herpesvirus family, and most particularly human cytomegalovirus. The method involves administering prophylactically or therapeutically effective amount of a cyclin-dependent kinase inhibitor to a patient or animal.
Claims27
A method for inhibiting proliferation of a mammalian DNA virus, the method comprising administering a prophylactically or therapeutically effective amount of a Cdk inhibitor to a patient or animal exposed to or infected by said virus.
A method for treating a patient infected with human cytomegalovirus, the method comprising parenterally administering a therapeutically effective amount of roscovitine and/or olomoucine to the infected patient.
Dependencies are inferred from the claim text.