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US 6,486,162 B2Granted
2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1- piperazinyl] propylthio}-4-pyrimidinol fumarate
AssigneeAbbott Laboratories
InventorsThomas Höger, Dorothea Starck, Hans-Jorg Treiber, Stefan Koser, Bernd Schaefer, Marco Thyes, Stefan Blank
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Abstract
The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3 ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.
Claims7
The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol of formula
- or a tautomeric form or a hydrate thereof.
Dependencies are inferred from the claim text.