Chemical compounds

A compound of Formula (1):

• wherein Ar1 represents:
• and wherein
• R5 is hydrogen, C1-4alkyl, phenylC1-4alkyl;
• R6 is hydrogen, C1-4alkyl, hydroxyC1-4alkyl, haloC1-4alkyl, dihaloC1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, sulfanylC1-4alkyl, aminoC1-4alkyl, N—(C1-4alkyl)aminoC1-4alkyl, N,N-di(C1-4alkyl)aminoC1-4alkyl or phenylC1-4alkyl;
• and
• m is 0, 1 or 2;
• R12 and R13 are independently hydrogen or C1-4alkyl;
• and
• Ar2 is phenyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, thienyl, thiazolyl, furyl or oxazolyl, the ring being substituted on ring carbon atoms by R2 and —(CH2)nR3, wherein Ar2 is attached to Ar1C(R12)R13CH═CH— by a ring carbon atom;
• or Ar2 is pyrrolyl, pyrazolyl or imidazolyl, the ring being substituted on ring carbon atoms or on the sp3 hybridised ring nitrogen by R2 and —(CH2)nR3, wherein Ar2 is attached to Ar1C(R12)R13CH═CH— by a ring carbon atom or the Sp3 hybridised ring nitrogen;
• and wherein
• R2 is a group of the Formula (2):
• wherein R7 is hydrogen or C1-4alkyl, R8 is —(CH2)q—R10 wherein q is 0-4 and R10 is C1-4alkylsulfanyl, C1-4alkylsulfinyl, C1-4alkylsulfonyl, hydroxy, C1-4alkoxy, carbamoyl, N—C1-4alkyl carbamoyl, N,N-(diC1-4alkyl)carbamoyl, C1-4alkyl, phenyl, thienyl, or C1-4alkanoylamino, R9 is hydroxy, C1-6alkoxy, C3-9cycloalkyloxy, heterocyclyloxy, heterocyclylC1-4alkoxy or —NH—SO2-R11 wherein R11 represents trifluoromethyl, C1-4alkyl, phenyl, heteroaryl, arylC1-4alkyl or heteroarylC1-4alkyl;
• or R2 represents a lactone of Formula (3)
• the group of Formula (2) or (3) having L or D configuration at the chiral alpha carbon in the corresponding free amino acid;
• or R2 is a group of the Formula (4):
• —CONHCH(R14)R15 Formula (4)
• wherein R14 is —(CH2)q—R16 wherein q is 0-4 and R16 is C1-4alkylsulfanyl, C1-4alkylsulfinyl, C1-4alkylsulfonyl, hydroxy, C1-4alkoxy, carbamoyl, N—C1-4alkylcarbamoyl, N,N-(diC1-4alkyl)carbamoyl, C1-4alkyl, phenyl, thienyl, or C1-4alkanoylamino;
• R15 is of the formula —CH2OR17 (wherein R17 is hydrogen, C1-4alkyl, phenyl, heteroaryl, C2-5alkanoyl, C1-4alkoxymethyl, phenoxymethyl or heteroaryloxymethyl), of the formula —COR18 or of the formula —CH2COR18 (wherein R18 is C1-4alkyl (optionally substituted by halo, cyano, C2-5alkanoyloxy, hydroxy, C1-4alkoxy or C1-4alkanoyl), phenyl, phenylC1-3alkyl, heteroaryl, heteroarylC1-3alkyl, C5-7cycloalkyl, C5-7cycloalkylC1-3alkyl, 2-(phenyl)ethenyl, 2-(heteroaryl)ethenyl or N-methoxy-N-methylamino);
• or R15 is morpholinoC1-4alkyl, pyrrolidin-1-ylC1-4alkyl or piperidin-1-ylC1-4alkyl wherein the morpholine, pyrrolidine and piperidine rings are optionally substituted by C1-4alkyl or C5-7cycloalkyl;
• or R15 is phenyl-1-hydroxycC1-4alkyl or heteroaryl-1-hydroxyC1-4alkyl;
• n is 0, 1 or 2;
• and
• R3 is phenyl or heteroaryl;
• and wherein phenyl and heteroaryl rings in R3, R5, R6, R11, R15 (including R17 and R18) are independently optionally substituted on ring carbon atoms by up to three substituents selected from C1-4alkyl, halogen, hydroxy, C1-4alkoxy, C1-4alkoxycarbonyl, C1-4alkanoyl, C1-4alkanoyloxy, amino, C1-4alkylamino, di(C1-4alkyl)amino, C1-4alkanoylamino, nitro, cyano, carboxy, thiol, C1-4alkylsulfanyl, C1-4alkylsulfinyl, C1-4alkylsulfonyl, C1-4alkanesulphonamido, N—(C1-4alkylsulphonyl)—N—C1-4alkylamino, aminosulfonyl, N—(C1-4alkyl)aminosulfonyl, N,N-di(C1-4alkyl)aminosulfonyl, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N-(diC1-4alkyl)carbamoyl, carbamoylC1-4alkyl, N—(C1-4alkyl)carbamoylC1-4alkyl, N,N-(diC1-4alkyl)carbamoylC1-4alkyl, hydroxyC1-4alkyl and C1-4alkoxyC1-4alkyl and on ring NH groups (replacing hydrogen) by C1-4alkyl, C1-4alkanoyl, C1-4alkylsulfonyl, haloC1-4alkyl, difluoromethyl or trifluoromethyl;
• or a pharmaceutically-acceptable salt, prodrug or solvate thereof.