A compound of formula I, or a pharmaceutically-acceptable salt thereof,
- wherein:
- A is a 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms selected from oxygen, nitrogen and sulphur wherein A may be optionally substituted by one, two or three atoms or groups selected from halo, oxo, carboxy, trifluoromethyl, cyano, amino, hydroxy, nitro, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxycarbonyl and, (1-4C)alkylamino or di-(1-4C)alkylamino;
- B is a phenylene or a 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen heteroatoms wherein B may be optionally substituted by halo, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylaminoethylamino, di-(1-4C)alkylamino, (2-4C)alkenyl, (2-4C)alkynyl, (2-4C)alkenyloxy, (2-4C)alkynyloxy, 4-(1-4C)alkylpiperazin-1-yl, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkylsulphonyl, (2-4C)alkanoylamino, (1-4C)alkanesulphonamido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, 4-(1-4C)alkylpiperazin-1-ylcarbonyl, (1-4C)alkanesulphonamidocarbonyl, (2-4C)alkanoyl, hydroxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, carboxy-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, carbamoyl-(1-4C)alkyl, N-(1-4C)alkylcarbamoyl-(1-4C)alkyl, or N,N-di-[(1-4C)alkyl]carbamoyl-(1-4C)alkyl;
- R and R1 are independently selected from hydrogen and (1-4C)alkyl;
- n is 1 or 2;
- R2 and R3, in combination with the nitrogen to which they are attached, form a 6-membered heterocyclic ring which may have in addition to the nitrogen atom 1 or 2 heteroatoms selected from nitrogen, oxygen and sulphur, wherein the heterocyclic ring formed from R2 and R3 may be optionally substituted by hydroxy, amino, carboxy, (1-4C)alkoxycarbonyl, oxo, (1-4C)alkyl, hydroxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, carboxy-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, or carbamoyl-(1-4C)alkyl;
- and
- Q is selected from phenyl, naphthyl, phenyl(1-4C)alkyl, phenyl(2-4C)alkenyl and a 5-, 6- or 7-membered heterocyclic ring containing up to 4 heteroatoms selected from nitrogen, oxygen and sulphur wherein Q may be optionally substituted by halo, halo(1-4C)alkyl, cyano, amino, hydroxy, carbamoyl, (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2-4C)alkenyloxy, (2-4C)alkynyloxy, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkylsulphonyl, (1-4C)alkylamino, di(1-4C)alkylamino, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbonoyl, (2-6C)alkanoyl, (2-4C)alkanoylamino, hydroxy-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, carboxy-(1-4C)alkoxycarbonyl-(1-4C)alkyl, carbamoyl-(1-4C)alkyl, N-(1-4C)alkylcarbamoyl-(1-4C)alkyl, N,N-di(1-4C)alkylcarbamoyl-(1-4C)alkyl, phenyl, phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl, benzyl, or benzoyl, wherein said phenyl, phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl, benzyl or benzoyl substituent bears 1, 2 or 3 substituents selected from halo, trifluoromethyl, cyano, hydroxy, amino, nitro, carboxy, carbamoyl, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di(1-4C)alkylamino, (1-4C)alkoxycarbonyl, N,-(1-4C)alkylcarbomoyl, N,N,(1-4C)alkylcarbamoyl and (2-4C)alkenoylamino.