Topical carbamazepine formulations and methods of use
AssigneeTaro Pharmaceutical Industries Ltd.
InventorsMarc Coles, Gad Keren
Life of this patent
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Abstract
A therapeutic formulation comprises a topically acceptable semisolid vehicle and carbamazepine, the vehicle consisting of components that are compatible with the carbamazepine, and the carbamazepine being in a concentration sufficient to permit a therapeutically effective amount of the carbamazepine to be absorbed from the formulation into the skin of a patient. The vehicle may be a cream, ointment, or gel. A method of treating a skin condition of a patient such as psoriasis comprises applying carbamazepine topically to the patient's skin until the condition improves. A method of administering carbamazepine to a patient comprises applying a formulation comprising carbamazepine topically to the patient's skin.
Claims27
A method of treating a psoriasis skin condition of a patient comprising applying carbamazepine topically to the patient's stkin repeatedly until the condition improves.
A method of administering carbamazepine comprising applying the carbamazepine topically at a site of a psoriasis skin condition, the carbamazepine having a localized therapeutic effect at the site.
A therapeutic formulation comprising a topically acceptable non-solid vehicle and carbarnazpine, the vehicle consisting of components that are compatible with the carbamazepine, and the carbarnazepine being in a concentration sufficient to permit a therapeutically effective amount of the carbamazepine to be absorbed from the formulation into the skin of a patient having a psoriasis skin condition when administered locally at a site of administration, the formulation having a localized therapeutic effect at the site of administration, and wherein the formulation is a gel consisting essentially of about 5% carbarnzepine, about 93% propylene glycol, and about 2% Carbomer 934 neutralized with sodium hydroxide.
A therapeutic formulation comprising a topically acceptable non-solid vehicle and carbamazepine, the vehicle consisting of components that are compatible with the carbamazepine, and the carbamazepine being in a concentration sufficient to permit a therapeutically effective amount of the carbamazepine to be absorbed from the formulation into the skin of a patient having a psoriasis skin condition when administered locally at a site of administration, the formulation having a localized therapeutic effect at the site of administration, and wherein the formulation is a cream consisting essentially of about 1% carbamazepine, about 50% propylene glycol, about 5% cetostearyl alcohol, about 1% sodium lauryl sulfate and about 43% water.
A therapeutic formulation comprising a topically acceptable non-solid vehicle and carbarnazepine, the vehicle consisting of components that are compatible with the carbamazepine, and the carbamazepine being in a concentration sufficient to permit a therapeutically effective amount of the carbamazepine to be absorbed from the formulation into the skin of a patient having a psoriasis skin condition when administered locally at a site of administration, the formulation having a localized therapeutic effect at the site of administration, and wherein the formulation is an ointment consisting essentially of about 3% carbamazepine, about 5% mineral oil, and about 92% petrolatum.
Dependencies are inferred from the claim text.