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US 6,486,143 B2Granted
6-amino- or 6-hydrazino-sulphonyl-3-quinolynyl-phosphonic acid compounds
AssigneeLes Laboratoires Servier
InventorsAlex Cordi, Patrice Desos, Pierre Lestage
Life of this patent
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Abstract
The invention relates to a compound of formula (I): wherein: R1 represents halogen or a group CF3, R2 represents hydrogen or alkyl or cycloalkyl, R3 is as defined in the description, R4 and R5 represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl a group Medicaments.
Claims16
A compound selected from those of formula (I):
- wherein:
- R1 represents halogen or trifluoromethyl,
- R2 represents hydrogen or alkyl or cycloalkyl,
- R3 represents alkyl, cycloalkyl, aryl, arylalkyl, alkoxy, aryloxy, arylalkoxy, hydroxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylcarbonyl, arylcarbonyl or arylalkylcarbonyl or NHR6 (wherein R6 represents hydrogen or alkyl, cycloalkyl, aryl, alkylcarbonyl, arylcarbonyl, arylalkyl or arylalkylcarbonyl),
- or R2 and R3 together form with the nitrogen atom carrying them a ring having 5 to 6 carbon atoms, in which one of the carbon atoms can be replaced by oxygen, nitrogen or sulphur or by SO, SO2 or NRa (wherein Ra represents hydrogen or alkyl, cycloalkyl, aryl or arylalkyl),
- R4 and R5, which may be identical or different, represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl or a group
- (wherein R7 and R8, which may be identical or different, represent hydrogen or alkyl, cycloalkyl or aryl),
- it being understood that:
- “alkyl” is understood to mean a linear or branched alkyl group containing from 1 to 6 carbon atoms,
- “alkoxy” is understood to mean a linear or branched alkoxy group containing from 1 to 6 carbon atoms,
- “cycloalkyl” is understood to mean a cyclic alkyl group containing from 3 to 8 carbon atoms,
- “aryl” is understood to mean the groups phenyl or naphthyl, it being possible for those groups to be unsubstituted or substituted by from 1 to 3 groups selected from alkyl, cycloalkyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, polyhaloalkyl, SO2NR9R10 (wherein R9 and R10, which may be identical or different, represent a hydrogen atom or an alkyl, cycloalkyl or aryl group) and halogen atoms,
- its enantiomers and diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid or base.
10 more elements
Dependencies are inferred from the claim text.