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US 6,486,137 B1Granted
Oligosaccharide mixtures having antithrombotic activity
AssigneeLeo Pharmaceutical Products Ltd. A/S
InventorsMons Lundqvist, Kristian Betton Johansen
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AssigneeLeo Pharmaceutical Products Ltd. A/S
InventorsMons Lundqvist, Kristian Betton Johansen
Estimating the term…
A mixture of linear oligosaccharides containing different numbers of repeating sulphated disaccharide units derived from L-iduronic acid (IdoA) and N-acetyl-D-galactosamine (Gal-NAc) and having the following characteristics (a) a molecular weight in the range of 1600-20000 for 90% or more of the mixture, (b) a sulphur content of 6.0-8.0% by weight, (c) a sulphate/carboxylate ratio of 1.2-1.6, (d) a disulphated disaccharide content of 20-60% by weight of the mono-sulphated disaccharide content, and (e) an antithrombin activity of 20-60 IU/mg. The mixture may be used as an antithrombotic agent and is prepared by depolymerisation of dermatan sulphate by periodate oxidation, followed by borohydride reduction and acid hydrolysis and then ion exchange fractionation.
A mixture of linear oligosaccharides prepared from dermatan sulphate, said mixture containing dermatan sulphate fragments of different chain lengths containing different numbers of repeating sulphated L-iduronic acid (IdoA) and N-acetyl-D-galactosamine (Gal-Nac) units according to the formula 1:
Dependencies are inferred from the claim text.