Gene treatment to enhance feed efficiency and growth rate of livestock
AssigneeLeaderGene Limited
InventorsFuk-ki Lee, Kai-Tong Tam, Sing-Fai Wai
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Abstract
This invention relates to the enhancement of feed efficiency and growth rate, and the reduction of fat accumulation to produce better quality meat by administration of an exogenous gene sequence comprising the complementary DNA sequence of growth hormone releasing factor to stimulate the production of the endogenous hormone peptide growth hormone. This invention further relates to methods for producing such gene sequence.
Claims19
A method of providing at least one of the effects of enhancing feed efficiencies, enhancing growth rates, or reducing fat accumulation in a porcine, said method comprising the step of administering an effective amount of a vector to the porcine to stimulate the production of growth hormone releasing factor (GHRF), wherein the vector comprises:
- a promoter including an actin promoter for gene expression;
- a DNA sequence encoding a GHRF signal peptide;
- and
- a porcine GHRF encoded DNA sequence comprising at least SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- wherein the vector is administered through intramuscular injection, and the promoter and the DNA sequence encoding the GHRF signal peptide are operably linked to the porcine GHRF encoded DNA sequence.
A vector to stimulate the production of growth hormone releasing factor (GHRF) to provide at least one of the effects of enhancing feed efficiencies, enhancing growth rates, or reducing fat accumulation in a porcine, wherein the vector comprises:
- a promoter including an actin promoter for gene expression;
- a DNA sequence encoding a GHRF signal peptide;
- and
- a porcine GHRF encoded DNA sequence comprising at least SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- wherein the promoter and the DNA sequence encoding the GHRF signal peptide are operably linked to the porcine GHRF encoded DNA sequence.
A method of manufacturing a vector to provide at least one of the effects of enhancing feed efficiencies, enhancing growth rates, or reducing fat accumulation in a porcine, said method comprising the steps of:
- joining a promoter including an actin promoter for gene expression, to a DNA encoding a growth hormone releasing factor (GHRF) signal peptide;
- and
- joining a porcine GHRF encoded DNA sequence comprising at least SEQ ID NO:
- 1 or SEQ ID NO:
- 2, to the DNA sequence encoding the GHRF signal peptide to form the vector.
Dependencies are inferred from the claim text.