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AssigneeStem Cell Pharmaceuticals, Inc.
InventorsDaniel R. Twardzik, Stefan Paskell, Thomas S. Felker
Estimating the term…
Disclosed are peptides related to human TGF-α, having TGF-α biological activity, which are useful for many of the indications that full-length TGF-α polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-α and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF-α related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.
A method of treating a subject having weight loss or at risk of losing weight due to an associated disease state, or treatment of a disease state comprising administering to the subject a transforming growth factor-alpha (TGF-α) polypeptide with a sequence of SEQ ID NO:
A method of increasing the body weight of a subject due to an associated disease state, or treatment of a disease state comprising administering to the subject prior to, simultaneously with, or substantially following weight-loss a transforming growth factor-alpha (TGF-α) polypeptide with a sequence of SEQ ID NO:
Dependencies are inferred from the claim text.