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US 6,485,987 B1Granted
Sol-gel matrices for direct colorimetric detection of analytes
AssigneesThe Regents of the University of California, Sandia Corporation
InventorsDeborah H. Charych, Darryl Sasaki, Stacey Yamanaka
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Abstract
The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.
Claims23
A method for detecting analytes, comprising:
- a) providing:
- i) colorimetric diacetylene polymers encapsulated in porous sol-gel glass;
- ii) a detector;
- and
- iii) a sample suspected of comprising one or more analytes;
- b) exposing said colorimetric diacetylene polymers encapsulated in porous sol-gel glass to said sample such that said one or more analytes in said sample reacts with said colorimetric diacetylene polymers causing a conformational change in said colorimetric diacetylene polymers, wherein said conformational change produces a colorimetric response;
- c) observing said colorimetric response using said detector;
- and
- d) correlating said response to the presence or absence of said one or more analytes id said sample.
6 more elements
A method for detecting analytes, comprising:
- a) providing:
- i) colorimetric diacetylene polymers encapsulated in porous sol-gel glass;
- and
- ii) a sample suspected of comprising one or more analytes;
- b) exposing said colorimetric diacetylene polymers encapsulated in porous sol-gel glass to said sample under conditions such that said one or more analytes in said sample reacts with said colorimetric diacetylene polymers causing a conformational change in said colorimetric diacetylene polymers, wherein said conformational change produces a colorimetric response;
- and
- c) observing said colorimetric response.
4 more elements
Dependencies are inferred from the claim text.