Calixcrown derivatives, a process for the preparation thereof, a self-assembled mono-layer of the calixcrown derivatives prepared by using the same and a process for immobilizing a protein mono-layer by using the self-assembled mono-layer of the calixcrown derivatives

Calix[4]aren-crown-5 derivatives of formula 2:

• wherein n is 1;
• R1, R2, R3 and R4 independently represent —CH2SH, —CH2Cl, —CH2CN, —CH2CHO, —CH2NH2, or —CH2COOH;
• or R1 and R3 represent —CH2SH, —CH2Cl, —CH2CN, —CH2CHO, —CH2NH2, or —CH2COOH, and R2 and R4 represent H;
• and R5 and R6 represent H, methyl, ethyl, propyl, isopropyl or isobutyl, respectively.

Calix[4]aren-crown-6 derivatives of formula 3:

• wherein n is 2;
• R1, R2, R3 and R4 independently represent —CH2SH, —CH2Cl, —CH2CN, —CH2CHO, —CH2NH2, or —CH2COOH;
• or R1 and R3 represent —CH2SH —CH2Cl, —CH2CN, —CH2CHO, —CH2NH2, or —CH2COOH, and R2 and R4 represent H;
• and R5 and R6 represent H, methyl, ethyl, propyl, isopropyl or isobutyl, respectively.