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US 6,485,958 B2Granted
Method for producing recombinant adenovirus
OwnerFrancis Blanche, Jean-Marc Guillaumeinventors
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Abstract
The invention concerns a method for producing recombinant adenovirus by which viral DNA is introduced in a packaging cell culture and the viruses produced are harvested after liberation in the supernatant. The invention also concerns the viruses produced and their use.
Claims19
A method for producing recombinant adenoviruses, the method comprising introducing adenoviral DNA into a culture of encapsidation cells, and harvesting adenoviruses following their release into culture supernatant without lysis of the encapsidation cells by an external factor.
Dependencies are inferred from the claim text.