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US 6,485,941 B1Granted
Inhibition of the carboxyltransferase component of acetyl-CoA carboxylase, and the use of such inhibition in anti-cancer and anti-lipogenic therapies
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsGrover L. Waldrop, Jacqueline M. Stephens, Keith L. Levert
Life of this patent
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Abstract
A method is disclosed for inhibiting carboxyltransferase with bisubstrate analogs. One such analog has been shown to inhibit the carboxyltransferase component of E. coli acetyl-CoA carboxylase. It is also expected to inhibit mammalian acetyl-CoA carboxylase, and thereby to act as an antiobesity agent and an anti-cancer agent.
Claims10
A method for inhibiting the carboxyltransferase activity of acetyl-CoA carboxylase, comprising reacting the acetyl-CoA carboxylase with a composition comprising Compound 1:
- phenylmethyl 5-(1-{[(2-{[N-(2,4-dihydroxy-3,3-dimethylbutanyl)-5-(6-aminooctahydro-9H-purin-9-yl)-4-(hydroxy-2-[(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate-β-alanyl]amino}ethyl)thio]acetyl}-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate;
- wherein the amount of the Compound 1 is sufficient to reduce the activity of carboxyltransferase by a statistically significant degree.
Dependencies are inferred from the claim text.