Broad spectrum infectious bursal disease virus vaccine
AssigneeAkzo Nobel N.V.
InventorsEgbert Mundt, Adriaan Antonius Wilhelmus Maria Loon Van
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Abstract
The present invention provides a broad spectrum IBDV vaccine that is able to induce a protective immune response against classical- and variant E IBDV strains. Moreover, the vaccine can be administered to poultry by mass application routes.
Claims15
An IBDV mutant comprising nucleotide sequences encoding a variant E VP2 protein in segment A of the viral genome thereof that is capable of infecting and replicating in chicken embryo fibroblast tissue culture (CEF), said mutant comprising one or more mutations in the variant E VP2 coding region such that,
- (i) the codon for the amino acid at position 254 encodes Glycine, and/or
- (ii) the codon for the amino acid at position 270 encodes Threonine.
A mutant IBDV comprising nucleotide sequences encoding a variant E VP2 protein in segment A of the viral genome thereof that is capable of infecting and replicating in chicken embryo fibroblast (CEF) tissue culture, wherein the coding region for the 253-284 fragment of the variant E VP2 protein is replaced by the corresponding coding region of IBDV strain D78.
Dependencies are inferred from the claim text.