Method for inhibiting CD95-independent apoptosis in AIDS
AssigneeDeutsches Krebsforschungzentrum Stiftung des Offentlichen Rechts
InventorsPeter Krammer, Christina Berndt
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Abstract
The invention relates to a method for inhibiting CD95-independent apoptosis, comprising the following steps: (a) blocking the bonding of HIV-1 gp120 on receptors CD4 and/or CXCR4 or of a factor competing for this bonding, and/or (b) inhibiting the signal path induced by the bonding of (a). The invention also relates to a system for identifying substances which can be utilized for inhibiting CD95-independent apoptosis.
Claims10
A method of inhibiting CD95-independent apoptosis, comprising the steps of:
- (a) blocking the bonding of HIV-1 gp120 to receptors CD4 and/or with a competing factor for said bonding, and/or
- (b) inhibiting the signal path induced by the bonding of (a).
A system for identifying substances suitable to inhibit CD95-independent apoptosis, comprising CD4+ and/or CXCR4+ cells, HIV-1 gp120, and a factor competing with HIV-1 gp120 for the bonding to CD4+ and/or CXCR4+.
Dependencies are inferred from the claim text.