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US 6,485,913 B1Granted
Systems and methods for performing reactions in an unsealed environment
AssigneeSequenom, Inc.
InventorsThomas Becker, Hubert Köster, Charles Cantor
Life of this patent
Estimating the term…
Abstract
Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of a liquid to a site on or in the support; a temperature controlling device for regulating the temperature of the support; and an interface for controlling the amount of liquid dispensed from the liquid dispensing system are provided. Methods using the systems are also provided.
Claims16
A system for performing a reaction, comprising:
- a support for performing the reaction;
- a nanoliter dispensing pipette for dispensing a submicroliter amount of a liquid onto the support;
- a temperature controlling device for regulating the temperature of the support;
- and
- means for controlling the amount of liquid dispensed, wherein:
- the amount of liquid dispensed corresponds to the amount of liquid that evaporates from the support;
- and
- the controlling means comprises software that calculates the amount of liquid that evaporates and signals the dispensing pipette to deliver an amount of liquid that corresponds to the amount that evaporates, wherein the system is open.
5 more elements
A system, comprising:
- a solid support having a target site for retaining or containing submicroliter quantities of a liquid;
- a liquid dispensing system for dispensing a liquid to the target site;
- a temperature controlling system, which regulates the temperature of the solid support;
- and
- an interface for indicating an amount of liquid to be dispensed to the target site, wherein the amount of liquid to be dispensed corresponds to an amount of liquid that evaporates from the target site.
2 more elements
A system, comprising:
- a solid support having a target site, which can contain a submicroliter amount of a liquid;
- a liquid dispensing system, which can dispense a liquid to the target site;
- a temperature controlling system, which regulates the temperature of the solid support;
- and
- means for regulating an amount of liquid dispensed from the liquid dispensing system, wherein the amount of liquid dispensed corresponds to an amount of liquid that evaporates from the target site, wherein the system is open.
2 more elements
Dependencies are inferred from the claim text.