Ras association domain containing protein
AssigneeIncyte Genomics, Inc.
InventorsMichael G. Walker, Tod M. Klinger, Randi E. Krasnow
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Abstract
The invention provides a mammalian cDNA which encodes a mammalian Ras association domain containing protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cell proliferative and inflammatory disorders, particularly thymus hyperplasia, allergies, asthma, and hypereosinophilia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Claims14
An isolated cDNA encoding a protein selected from:
- a) a protein having an amino acid sequence of SEQ ID NO:1;
- and
- b) an antigenic epitope of a protein having an amino acid sequence of SEQ ID NO:1.
An isolated cDNA comprising a polynucleotide selected from:
- a) a polynucleotide having a nucleic acid sequence of SEQ ID NO:2;
- b) a polynucleotide having a nucleic acid sequence selected from SEQ ID NOs:3-9, 11 and 12;
- and
- c) a complement of a)-b).
Dependencies are inferred from the claim text.