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US 6,485,899 B1Granted
Anti-bacterial methods and materials
AssigneePharmacia & Upjohn Company
InventorsDavid Holden, Ji Min Mei
Life of this patent
Estimating the term…
Abstract
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel S. aureus mutants useful in vaccines.
Claims12
A method of screening for a potential anti-bacterial agent comprising the steps of:
- (a) contacting a bacterial protein represented by any one of SEQ ID NOs:
- 12, 61 or 66 (corresponding to signature tag identification numbers, p5c4, p9b65, and p10b89) with a chemical compound, wherein said chemical compound is a candidate anti-virulence agent, and
- (b) identifying said chemical compound as a potential anti-bacterial agent that interferes with the function of said bacterial protein when said chemical compound binds to or interacts with said bacterial protein wherein the function of said protein is to confer bacterial virulence.
A method of screening for a potential anti-bacterial agent comprising the steps of:
- (a) contacting a bacterial protein represented by SEQ ID NO:
- 66 with a chemical compound, and
- (b) identifying said chemical compound as a potential anti-bacterial agent that interferes with the function of said bacterial protein when said chemical compound binds to or interacts with said bacterial protein wherein the function of said protein is to confer bacterial virulence.
Dependencies are inferred from the claim text.