Resorbable calcium phosphate-based bio-compound particles and the manufacturing procedure thereof
AssigneeIndustrial Technology Research Institute
InventorYng-Jiin Wang
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Abstract
This specification discloses resorbable calcium phosphate-based bio-compound particles and the manufacturing method thereof. Through the manufacturing process control, collagen has sufficient time to reconstruct and forms a network structure, which then combines with calcium phosphate-based ceramic powders that are controlled to have diameters ≦5 μm so as to provide a bio-compound acceptable by humans and having a similar structure and constituents to the bony tissues. There is no need for a second operation when such material is used in medical practice and the bony tissues can undergo fast and effective bone-genesis.
Claims17
A manufacturing procedure for preparing resorbable calcium phosphate-based bio-compound particles, which comprises the steps of:
- mingling collagen and calcium phosphate-based ceramics powders into a mixture solution;
- adding the mixture solution by droplets into an oil phase in such a manner so as to cause the mixture solution to undergo reconstitution and form particles with a network structure;
- adding a cross-linking agent to the oil phase for the particles to cross-link;
- and
- isolating the particles from the oil phase;
- wherein the cross-linking agent is selected and process is conducted such that the particles prepared from the calcium phosphate-based ceramics powders have a dimension ≦5 μm.
A resorbable calcium phosphate-based bio-compound particle, comprising:
- collagen with a network structure;
- and
- calcium phosphate-based ceramics powders with an average diameter ≦5 μm homogeneously distributing in the network structure of collagen.
Dependencies are inferred from the claim text.