Method and composition of an oral preparation of itraconazole
AssigneeChoongwae Pharma Corporation
InventorsJae-Young Jung, Kye-Hyun Kim, Sang-Heon Lee, Ji-Woong Hong, Jong-Woo Park, Kyu-Hyun Lee
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Abstract
The present invention relates to a method and composition of an oral preparation of itraconazole, an excellent azole antifungal drug. More particularly, it relates to an oral preparation of itraconazole having improved bioavailability, which is prepared by following steps of: i) dissolving itraconazole and bydrophilic polymer with solvent, ii) spray-drying said mixture, and iii) preparing the solid dispersions for oral preparation. The solid dispersions prepared in this invention may be useful in preparing tablets, granules and other oral dosage forms.
Claims4
An oral preparation of itraconazole having improved bioavailability, which is prepared by dissolving 1.0 to 2.5 wt parts of at least one pH-dependent inert hydrophilic polymer selected from the group consisting of polyvinylacetal dithylarmoacetate and aminoalkyl methacrylate copolymer with 1.0 wt part of itraconazole in at least one solvent selected from the group consisting of methylenechloride, chloroform ethanol and methanol, and subjecting the resulting solution obtained after the dissolution to a dispersing and spray-drying process, to prepare particles of a solid dispersion consisting of itraconazole and said hydrophilic polymer for the manufacture of an oral preparation.
Dependencies are inferred from the claim text.