Transdermal methotrexate preparations
AssigneeYutoku Pharmaceutical Ind., Co., Ltd.
InventorsKenji Tominaga, Takaaki Hamada
Life of this patent
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Abstract
A methotrexate-containing transdermal preparation effective for rheumatoid arthritis comprises an organic amine. The organic amine may preferably be an alkonolamine such as monoethanolamine, diethanolamine, triethanolamine or diisopropanolamine, or an alkylamine such as ehtylamine, diethylamine or triethylamine. The transdermal preparation is, for example, a plaster, a cataplasm, an ointment, a cream or a lotion.
Claims16
A method for delivering methotrexate into the blood comprising:
- transdermally administering to a subject in need of treatment a composition comprising:
- methotrexate and at least 2 wt. % of an alkylamine or an alkanolamine selected from the group consisting of ethylamine, diethylamine, triethylamine, monoethanolamine, diethanolamine, triethanolamine and diisopropanolamine.
A product or preparation that delivers methotrexate transdermally into the blood, comprising:
- methotrexate and
- at least 2 wt. % of an alkylamine or an alkanolamine selected from the group consisting of ethylamine, diethylamine, triethylamine, monoethanolamine, diethanolamine, triethanolamine, and diisopropanolamine.
A rubber-based elastomer or acrylic adhesive comprising:
- methotrexate and
- at least 2 wt. % of an alkylamine or an alkanolamine selected from the group consisting of ethylaamine, diethylamine, triethylamine, monoethanolamine, diethanolamine, triethanolamine and diisopropanolamine.
A transdermal preparation, comprising:
- methotrexate and
- at least 2 wt. % of an alkylamine or an alkanolamine selected from the group consisting of ethylamine, diethylamine, triethylamine, monoethanolamine, diethanolamine, triethanolamine and diisopropanolamine.
Dependencies are inferred from the claim text.