Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles and methods of using the same

A pharmaceutical composition for delivery of a biologically active substance, comprising:

• (a) a biocompatible polymer composition, comprising:
• (i) at least one biologically active substance;
• and
• (ii) a biocompatible polymer comprising the following structure:
• wherein R is a divalent organic moiety;
• R′ is an aliphatic, aromatic or heterocyclic residue;
• x is ≧1;
• and n is 3-7,500;
• and
• (b) a pharmaceutically acceptable carrier,
• wherein implantation or injection of said pharmaceutical composition into the body of an animal provides controlled delivery of said biologically active substance.

A biodegradable therapeutic agent delivery system, comprising:

• (a) a biocompatible polymeric composition comprising:
• (i) at least one therapeutic agent;
• and
• (ii) a biocompatible polymer comprising the following moiety:
• wherein R is a divalent organic moiety;
• R′ is an aliphatic, aromatic or heterocyclic residue;
• x is ≧1;
• and n is 3-7,500;
• and
• (b) a pharmaceutically acceptable carrier.

A microsphere composition, comprising:

• (a) at least one biologically active substance;
• and
• (b) a biocompatible polymer comprising the following formula:
• wherein R is a divalent organic moiety;
• R′ is an aliphatic, aromatic or heterocyclic residue;
• x is ≧1;
• and n is 3-7,500;
• wherein said microsphere composition is formulated in form of microspheres.

A method for the controlled release of a biologically active substance, comprising administering to an animal at a preselected site microspheres comprising a biologically active substance and a polymer having the recurring monomeric units:

• wherein
• R is a divalent organic moiety;
• R′ is an aliphatic, aromatic or heterocyclic residue;
• x is ≧1;
• and n is 3-7,500;
• wherein said polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation, and wherein said microspheres are in least partial contact with a biological fluid of said animal after administration.